Is Carpal Tunnel Genetic?

From Dr. Z - Carpal tunnel syndrome specialist

Is Carpal Tunnel Genetic?

The answer is Yes - carpal tunnel is genetic. This painful, numbing, and progressive disorder is definitely linked to family history. And recent studies show it's far more prevalent in women than anybody ever imagined.

Table of Contents

  • Who gets carpal tunnel?
  • Symptoms of carpal tunnel
  • High risk jobs
  • High risk health factors
  • Why carpal tunnel is genetic
  • Problems with collagen
  • Anatomical problems
  • Carpal tunnel is also a "female condition"
  • Manual labor considerations
  • Diagnosing carpal tunnel syndrome
  • Treatment: 4 core carpal tunnel stretching exercises
  • "Stop" stretching exercise
  • "Prayer" stretching exercise
  • Finger interlace stretching exercise
  • Thumb stretching exercise
  • Summary



Johnson & Johnson

Who gets carpal tunnel?

Symptoms of carpal tunnel

Most people with carpal tunnel syndrome have specific signs and symptoms in their hand or fingers. These can include any of the following:


In the beginning stages of the disorder, symptoms usually appear only at night. In time, symptoms start to appear during the daytime as well. In the severe stage, symptoms are constant. The thumb and index finger are most likely to be involved first. The little finger never has symptoms.

gripping a hairbrush

High risk jobs

When you see your doctor he or she will perform a physical exam to diagnose the problem. During the exam, the first question the doctor will ask is if you have a family member with carpal tunnel syndrome. Having a family member with carpal tunnel almost confirms the diagnosis.


In other words, a major risk factor for getting carpal tunnel is family history or genetics. Another risk factor is your occupation. Certain jobs are high risk for getting carpal tunnel. In fact, some industries are infamous for having this disorder. For instance, with hairdressers, carpal tunnel syndrome is number 4 among their top 3 health concerns. And 15% of them already have this condition.


Other notable occupations infamously associated with carpal tunnel include:

guitar player

High risk health factors

Other major risk factors for this disorder include certain health conditions. The conditions commonly making you more prone to getting carpal tunnel include:

Why carpal tunnel is genetic

Carpal tunnel syndrome occurs in families. The hereditary nature of carpal tunnel syndrome means if you have it, then your children will likely sufferer as well. Likewise, if a sibling has it, then you're also at high risk. And if you're a female with a parent who had carpal tunnel syndrome, then you're at extremely high risk.


No one is really certain which specific genetic factor or factors cause carpal tunnel syndrome. But two possible candidates have been proposed: problems with collagen and anatomical problems.

gripping a hairbrush

Problems with collagen

The pathology of carpal tunnel syndrome begins in the tendons and other connective tissues inside the wrist joint. Stiffer or less strong collagen fibers in tendons will make them less strong. This can lead to tendon failure. This then can result in tendon inflammation and swelling. The tendon swelling crushes the adjacent median nerve (see illustration) which is the basis of carpal tunnel syndrome.


Evidence suggests that certain genes make tissue proteins (like collagen) which are not optimal for strength or suppleness. In other words, the collagen is defective. Examples are defects in Type V collagen, which has been shown to be present in people with carpal tunnel syndrome.

Anatomical problems

Genes also control our physical characteristics. They contain the code for how tall or wide we become. They also code for the diameter of our limbs, and in particular, our wrists.


Statistics show that more slightly built ("small boned") individuals are at higher risk for developing carpal tunnel syndrome. And if you inherited a smaller body frame including a smaller wrist diameter, you're at even higher risk for the disorder.

Carpal tunnel is also a “female condition”

The well-known fact is that females are 3-5 times more likely to develop carpal tunnel syndrome than males. This is why many scientists consider it primarily a female condition.


But the reason it's a primarily female condition is not just due to more narrow wrists commonly seen in females. It's more than that. One hint comes from Dr. Kramer and others. They have shown that females with carpal tunnel syndrome tend to have elevated levels of Type II collagen. Such an increase may change the surface of cartilaginous structures. This change impacts how tissues can handle mechanical loads, and by extension, can lead to tendon failure.

female construction worker

Manual labor considerations

The consequences of repetitive stress cannot be understated. Repetitively stressing your fingers and hands is a major risk factor for developing carpal tunnel syndrome. And the major source of repetitive stress is related to the work environment.


Males make up slightly more than half of the US labor force. And in that workforce, females produce only 10% of the manual labor performed.


Adjusting for this disparity means that women are exposed to manual labor 9 times less than males. Yet they are more prone to carpal tunnel! Therefore, the probability of women developing carpal tunnel syndrome (under equal working environments) is not 2-3 times higher, but over 30 times higher than in males!


By any measure, this reinforces the idea that carpal tunnel syndrome is primarily a "female condition".

3 provocative carpal tunnel tests

Diagnosing carpal tunnel syndrome

The most reliable way a doctor can diagnose carpal tunnel syndrome is by using 3 "provocative tests". These are the Phalen, Tinel, and Durkan tests. They represent reliable ways to determine if you have carpal tunnel syndrome instead of another condition, like wrist tendonitis. 


Basically, the doctor taps and presses on your wrist area. If the doctor can "provoke" symptoms (or make them worse) then it's positive for having carpal tunnel syndrome.



Unfortunately, many doctors still rely heavily on electromyography (EMG), MRI, and CT exams to diagnose carpal tunnel syndrome. But the American Academy of Neurology says such tests are valueless compared to the 3 simple and precise provocative tests. In other words, the electronic tests should be used only to confirm the provocative diagnosis.

doctor performing EMG test for carpal tunnel

Treatment: 4 core carpal tunnel stretching exercises

The most important partner you have against fighting carpal tunnel syndrome is a stretching exercise regimen. If you do these 4 core stretching exercises every 1-2 hours, then your carpal tunnel symptoms will usually disappear in just a few weeks. And they certainly will never get worse.

1. "Stop" stretching exercise

stop stretch for carpal tunnel

This exercise stretches the portion of the flexor tendons in your wrist joint.


Hold your arm outstretched in front of you. Next, put your fingers up like you’re saying “Stop!” With your opposite hand, bend the “stop” fingers backward and hold them.  As a result your forearms will feel tight. Hold for 5 seconds then drop you hand. Shake it out and repeat. Then switch hands. 


Next, reverse the “Stop!” position so your fingers point downward. Use your other hand to pull your downturned fingers for 5 seconds. Drop your hand, shake it out, and repeat. Then switch hands and start over. 

2. "Prayer" stretching exercise

prayer position exercise for carpal tunnel

This exercise stretches a long length of your forearm flexor tendons. 


Push your palms together in a “prayer” position with fingers pointing up. Next, pull your hands close to your chest and raise both elbows. But keep your hands at the same elevation as you do so. As a result, you’ll feel tightness in your forearms. Hold the position for 5 seconds then drop your hands. Shake them out, and repeat.

3. Finger interlace stretching exercise

finger interlace carpal tunnel stretch

This exercise focuses on stretching the flexor tendons in your fingers.


With palms together, interlace the fingers of both hands. Next, rotate your hands so your palms face forward. Straighten you elbows and extend your hands away from you. Consequently, you’ll feel your fingers and forearms tighten. 


Hold this position for 5 seconds. Then drop you hands and shake them out.

4. Thumb stretching exercise

thumb stretch for carpal tunnel

This stretch focuses on the thumb because it's the finger most affected by carpal tunnel syndrome.


Grab a thumb and gently rotate it like a helicoptor blade. Rotate several times in one direction. Then switch direction for a few more times.


Finally, gently pull back on the thumb until you feel the stretch. But don't over-do it. Then switch hands and repeat.

Summary

Carpal tunnel is related to genetics. Having a parent or sibling with this condition is a good way to predict if you’ll also see symptoms. In other words, you're at high risk if there's a hereditary link. Also, if you're female, you're at high risk as well. That means having both risk factors almost assures you'll get carpal tunnel syndrome. But you don’t have to let carpal tunnel control your life. Just perform the simple stretching exercises described here.

About

Biography: Dr. Z - CarpalRx Medical Director & author

Dr. Maik Zannakis (Dr. Z) 

Medical Director at the CarpalRx


Dr. Z is an acclaimed medical scientist renowned for his expertise in carpal tunnel syndrome and soft tissue disorders. With over 40 years of experience, he is credited with hundreds of medical journal publications and hundreds more web articles about carpal tunnel syndrome. After inventing the CarpalRx, Dr. Z became the go-to expert for carpal tunnel syndrome and wrist tendonitis. His opinions, inventions, and personalized care have distinguished Dr. Z as a trusted leader in this growing field. Read full Bio


Email: dr.z@carplarx.com

Phone: 800-450-6118